This study actually may mean that there may be an insight to treat , Subclinical hypothyroidism which is defined biochemically as a normal serum free thyroxine (T4) concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration.
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Does fasting or postprandial state affect thyroid function testing?
Alteration in TSH values may affect diagnosis and management of hypothyroidism, particularly subclinical hypothyroidism (SCH).
Some patients with subclinical hypothyroidism may have vague, non-specific symptoms suggestive of hypothyroidism, but attempts to identify patients clinically have not been successful so far.
Subclinical hypothyroidism is a condition in which free thyroxine (T4) is within normal range while Thyroid Stimulating Hormone (TSH) is elevated.
SCH may cause several long term effects that include dyslipidemia, hypertension, and subfertility. It may also serve as an independent risk factor for cardiovascular morbidity. Level of TSH varied throughout the day and may be related to presence of food. Present study demonstrates the effect of fasting or postprandial state in analysis of thyroid function tests.
This study was carried out in 57 patients.
Thyroid functions test were carried out in fasting state and 2 hours postprandially. TSH values were found to be significantly lowered in all the three groups postprandially but no change in free T4 values were observed.
It was observed that there is significant fall in TSH levels postprandially when compared to fasting values.
Source: Nair R et al. Does fasting or postprandial state affect thyroid function testing? Indian J Endocrinol Metab. 2014; 18(5):705-7. more