Narender, Prabhakar is right. In US we call urticaria hives and they can make the sufferer miserable. Your wife needs to see a doctor to establish what is causing the hives. Believe me, there are so many causes from allergies to food, medications, insect stings or bites, pressure, heat, cold, exercise, sun exposure, latex, bacterial infections such as urinary tract infections and strep throat, blood transfusions, pollen, pet dander, contact with poisonous plants such as poison ivy and poison oak, etc. As you can see there are so many causes that going to the doctor will help narrow the causative agents down to a few. A complete medical history can narrow down some of the suspects and allergy testing can narrow it down further. Once the causative agent is identified, the proper medication can be given and the hives will diminish and disappear within a week, if not sooner. Sometimes however it is harder to pin down. Reactions to the sun, a delayed reaction after exercising, pressure, may be harder to pin down, as will some food allergies. Food allergies that manifest immediately are easy to distinquish and treatment given and avoidance is necessary. Some food allergies are different. They are very difficult to pin down since the food is digested by many enzymes. We can be allergic to any one of the intermediate stages of the food's digestion. For example I can eat mushrooms with no problems, but within two hours I will have an asthma attack. Others will suffer from hives. Having suffered for two years your wife truly needs relief. Sometimes the doctor will prescribe steroids to knock down the hives fast. This will bring relieve while they are looking for the causative agent. I would think that having suffered for two years that the causative agent must be ever present in your home, or in a food she eats, or a pet, pollen from plants around your home, perfumes, lotions, candles, cleaning produces, to name a few. The doctor can give her an elimination diet to rule out food sources. If it is something that can't be avoided, antihistamines can be used. These block the IgE-primed mast cells which release granules and chemical mediators, one of which is histamine. Histamine causes allergy reactions such as a stuffy nose, difficulty breathing, asthma or hives, hence the use of antihistamines. Let us know how things are progressing with your wife's condition. I wish the best in your search for a cure.
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